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Home > Products > Anticancer APIS > Anti-cancer API Brigatinib cas 1197953-54-0 with high quality AP26113

Anti-cancer API Brigatinib cas 1197953-54-0 with high quality AP26113
Anti-cancer API Brigatinib cas 1197953-54-0 with high quality AP26113

Anti-cancer API Brigatinib cas 1197953-54-0 with high quality AP26113

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

    Model No.: CAS 1197953-54-0

Additional Info

    Packaging: 10g 100g 1kg

    Productivity: 100 kg/month

    Brand: cy

    Transportation: Ocean,Land,Air

    Place of Origin: China

    Supply Ability: 50kg

    Certificate: ISO 9001, GMP

    Port: QINGDAO,SHANGHAI

Product Description

What is Brigatinib?

Brigatinib is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Brigatinib binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.


Brigatinib, also known as AP-26113, is an orally active, potent and selective Dual ALK/EGFR inhibitor. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.


Product name

Brigatinib

CAS NO. 1197953-54-0
Synonyms

Brigatinib;AP26113

Category Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
Purity 99% Brigatinib
Appearance

Brigatinib powder

Shelf life 2 years
COA

Please email us for the coa of brigatinib.

Usage

Brigatinib acts as both a anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR) inhibitor.
Brigatinib could overcome resistance to osimertinib conferred by the EGFR C797S mutation if it is combined with an anti-EGFR antibody such as cetuximab or panitumumab.

Storage Brigatinib should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.



Looking for ideal Brigatinib Fda Approval Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Brigatinib Side Effects are quality guaranteed. We are China Origin Factory of Ap26113 Clinical Trial. If you have any question, please feel free to contact us.

Product Categories : Anticancer APIS

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