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Home > Products > Anticancer APIS > Dacomitinib (PF299804) CAS 1110813-31-4

Dacomitinib (PF299804) CAS 1110813-31-4
Dacomitinib (PF299804) CAS 1110813-31-4

Dacomitinib (PF299804) CAS 1110813-31-4

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 10 Gram
Delivery Time: 3 Days

Basic Info

    Model No.:  CAS 1110813-31-4

Additional Info

    Packaging: 10g 100g 1kg

    Productivity: 100 kg/month

    Brand: cy

    Transportation: Ocean,Land,Air

    Place of Origin: China

    Supply Ability: 50kg

    Certificate: ISO 9001, GMP

    Port: QINGDAO,SHANGHAI

Product Description



Dacomitinib package insert

Dacomitinib is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.

dacomitinib mechanism of action


Dacomitinib is a selective and irreversible inhibitor of EGFR. It is a drug candidate for the treatment of non-small cell lung carcinoma. It is current under the Phase III clinical trials. It also shows potential for the treatment of HER-2 amplified breast cancer cells lines that are resistant to trastuzumab and lapatinib.

dacomitinib fda approval

Dacomitinib is taken orally once-daily. It is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. Dacomitinib targets multiple receptors of the HER pathway, whereas currently marketed HER-1 (EGFR) inhibitors for non-small cell lung cancer (NSCLC) target only one receptor in this pathway,developed by Pfizer.

Product Name Dacomitinib
Synonyms PF-299804 (Dacomitinib,PF-00299804);PF299804, PF299);Dacomitinib;PF-00299804-03;PF-00299804;DacoMitinib (PF-00299804);DacoMitinib,PF299804;DacoMitinib (PF299804,PF-00299804)
CAS 1110813-31-4
MF C24H25ClFN5O2
MW 469.9390032
EINECS N/A
Product Categories -;Anti-cancer&immunity;Inhibitors
Mol File 1110813-31-4.mol
dacomitinib breast cancer




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Product Categories : Anticancer APIS

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