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Home > Products > Hot sellers API > Cas 115256-11-6 Dofetilide High quality Dofetilide

Cas 115256-11-6 Dofetilide High quality Dofetilide
Cas 115256-11-6 Dofetilide High quality Dofetilide
Cas 115256-11-6 Dofetilide High quality Dofetilide

Cas 115256-11-6 Dofetilide High quality Dofetilide

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 100 Gram
Delivery Time: 3 Days

Basic Info

    Model No.: Cas 115256-11-6

Additional Info

    Packaging: 100g 1kg

    Productivity: 100 kg/month

    Brand: chenyi

    Transportation: Ocean,Land,Air

    Place of Origin: China

    Supply Ability: 50 kg

    Certificate: ISO 9001,GMP


Product Description

Dofetilide API 115256-11-6 professional supplier




Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.


Antiarrhythmic Agents, Potassium Channel Blockers, Anti-Arrhythmia Agents

CAS number 115256-11-6
Weight Average: 441.565
Monoisotopic: 441.139212369
Chemical Formula C19H27N3O5S2
Indication For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
Pharmacodynamics Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm. Dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. At concentrations covering several orders of magnitude, Dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, Dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.
Mechanism of action The mechanism of action of Dofetilide is a blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. This inhibition of potassium channels results in a prolongation of action potential duration and the effective refractory period of accessory pathways (both anterograde and retrograde conduction in the accessory pathway).
Absorption >90%
Volume of distribution

3 L/kg

Protein binding 60% -70%
Affected organisms

Humans and other mammals

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