Communicate with Supplier? Supplier
Jerry Mr. Jerry
What can I do for you?
Chat Now Contact Supplier

Shandong Chenyi Environmental Protection Technology Co.,Ltd

Products

Home > Products > Hot sellers API > CAS 120011-70-3 GMP Certified Donepezil Hydrochloride / Donepezil hcl

CAS 120011-70-3 GMP Certified Donepezil Hydrochloride / Donepezil hcl
CAS 120011-70-3 GMP Certified Donepezil Hydrochloride / Donepezil hcl

CAS 120011-70-3 GMP Certified Donepezil Hydrochloride / Donepezil hcl

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 100 Gram
Delivery Time: 3 Days

Basic Info

    Model No.: CAS 120011-70-3

Additional Info

    Packaging: 100g 1kg

    Productivity: 1000 kg/month

    Brand: chenyi

    Transportation: Ocean,Land,Air

    Place of Origin: China

    Supply Ability: 500 kg

    Certificate: ISO 9001,GMP

    Port: QINGDAO,SHANGHAI

Product Description

Description

Superlist Name:Donepezil

Molecular Formula:C24H29NO3

CAS No.:120014-06-4

Purity:99%

Synonyms:2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Molecular Weight:379.49

Appearance:white powder

Melting Point: 207 °C

Application

Shown to increase levels of cortical acetylcholine

1. General info:Donepezil (also misspelled donezepil), is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. Its binding to the acetylcholinesterase can be seen at Proteopedia 1eve. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks, and then after 3 months can be titrated to 23mg if needed.

2.Other indications: Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome. A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

Specification

TEST ITEM

SPECIFICATION

RESULT

Appearance

Off white to white crystalline powder

Complies

Solubility

freely Freely soluble in chloroform, soluble

in water and Acetic acid, slightly soluble in

Acetonitrile and ethanol, insoluble in

Ethylacetoacetate and n-hexane

Complies

Identification

(1)By IR absorption ,To match with working

standard

Complies

(2) The retention time of the major peak of

the sample should accord with that of the

working standard.

Complies

(3) Test for chlorides. Reponds to the test

for Chlorides.

Complies

PH

4.0-7.0

6.10

Residue on ignition

≤0.1%

0.03%

Related substance

Any Unkonwn single impurity≤0.3%

Total ≤0.5%

0.04%

0.18%

Heavy metal

≤10ppm

<10ppm

Residual Solvents

Methanol≤0.3%

Ethanol≤0.5%

Ethyl acetate≤0.5%

Toluene≤0.089%

Acetic acid≤0.5%

Not detected

Not detected

Not detected

Not detected

Not detected

Loss on drying

≤0.5%

0.20%

Assay

On dried base, C24H29NO3·HCl

should be 98.0% to 102.0%

98.20%

Conclusion: The product complies to Enterprise standard



Looking for ideal Onepezil Hcl 5 Mg Side Effects Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Donepezil Hydrochloride Side Effects are quality guaranteed. We are China Origin Factory of Donepezil Hydrochloride Tablets. If you have any question, please feel free to contact us.

Product Categories : Hot sellers API

Send Inquiry

Tel:86-0531-18560179988

Fax:

Mobile Phone:+8613561750134Contact me with Whatsapp

Email:Sales@chenyichemistry.com

Address:No.215 Beiyuan Main street,tianqiao District, Jinan, Shandong