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Home > Products > Hot sellers API > Antineoplastic drug Irinotecan hydrochloride CAS 100286-90-6

Antineoplastic drug Irinotecan hydrochloride  CAS 100286-90-6

Antineoplastic drug Irinotecan hydrochloride CAS 100286-90-6

Payment Type: L/C,T/T,Paypal
Incoterm: FOB,CIF
Min. Order: 1 Kilogram
Delivery Time: 2 Days

Basic Info

    Model No.: CAS 100286-90-6

Additional Info

    Packaging: 50kg

    Productivity: 3 T/year

    Brand: cy

    Transportation: Ocean,Land,Air

    Place of Origin: China

    Supply Ability: 2T

    Certificate: GMP

    Port: QINGDAO,SHANGHAI

Product Description

Irinotecan Hcl


CAS Number 100286-90-6


Synonyms Topotecin Hydrochloride


Molecular Formula C33H39ClN4O6


Molecular Weight 623.139


Melting Point 250-256ºC (dec.)


Boiling Point 257 ºC


Flash Point 482°C


Introduction:



Antineoplastic agents. Inhibitors for DNA synthesis. Is a semisynthetic derivative of camptothecin. Antineoplastic agents. Inhibitors for DNA synthesis. It is a semisynthetic derivative of camptothecin, used for the preparation of irinotecan hydrochloride and irinotecan hydrochloride three hydrate, and is an anticancer drug. Irinotecan, a topoisomerase I inhibitor, is primarily used in the treatment of colorectal cancer and is usually associated with other chemotherapeutic agents


Irinotecan, is a medication used to treat colon cancer and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is used with cisplatin. It is given by slow injection into a vein.


Application:



Mainly used in the treatment of digestive system tumors such as gastric cancer, colon cancer, rectal cancer, lung cancer and so on, also used to treat leukemia, hydatidiform mole and chorionic carcinoma. The stand for kang is a through chemical structure modification of natural derivative of camptothecin. It's curative effect, less toxic and side effect of new cancer drugs, mainly used in the treatment of lung cancer, colorectal cancer, gastric cancer, cervical cancer, ovarian cancer and other cancers.

Specifications



Items Specifications
Appearance Pale yellow or yellow crystalline powder,odorless
Identification
a) IR IR chromatograph Conforms to the characteristic peak of R.S.
b) HPLC

The retention time of the majorpeak in the chromatogram

Conforms to the characteristicpeak of R.S.

Specific rotation +61.0º~+69.0º
Water 7.0%~9.0%
Residue on ignition Not more than 0.1%
Heavy metal Not more than 10ppm
Irinotecan Hydrochloride R-enantiomer Not more than 0.15%
Camptothecin Not more than 0.15%
10-Hydroxycamptothecin Not more than 0.15%
7-Ethyl-10-hydroxycamptothecin Not more than 0.15%
7,11-Diethyl-10-hydroxycamptothecin Not more than 0.15%
7-Ethyl camptothecin Not more than 0.15%
7-Desethylirinotecan Not more than 0.15%
11-Ethyl camptothecin Not more than 0.15%
Any unknown individual impurity Not more than 0.10%
Total impurities Not more than 0.50%
Assay[calculated on anhydrous basis] 98.0%~102.0%
Residue solvents
n-Hexane Not more than 290ppm
Methanol Not more than 3000ppm
Acetone Not more than 5000ppm
Pyridine Not more than 200ppm
Dichloromethane Not more than 600ppm
Ethanol Not more than 5000ppm
Staphylococcus aureus, pseudomonas

aeruginosa, salmonella species, and

Escherchia coli

Absence
Bacterial ensotoxin Not more than 0.556 EU/mg
Microbial limits
Total aerobic microbial Not more than 1000cfu/g
Molds and yeasts Not more than 100cfu/g

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